The primary purpose of this study is to investigate the relationships between adolescents’ global self-esteem and domain-specific self-concepts in Taiwan.  Using Chinese Rosenberg Self-Esteem Scale (CRSES) and Chinese Self-Description Questionnaire-II (CSDQ-II), 591 subjects from the junior and senior high schools in Taiwan reported their perceptions to global self-esteem and self-concept in this study.  Correlation, multiple regression analysis and analysis of variance (ANOVA) were applied to the data collection. The major findings were as follows: (a) the correlation coefficients among the factors of CSDQ-II and the CRSES were statistically significant; (b) 6 specific domains of self-concept (i.e., math/school, verbal, physical appearance, emotion, parent relations and per relations) made significant contribution to predict adolescents’ global self-esteem; (c) gender and differences had an impact on adolescents’ perception to domain-specific self-concepts; (d) a significant two-way interaction between grade and gender was found on the factor of peer relationships.