The purpose of the study was to investigate the effects of stimulus changes on orienting reflex (OR) and the relationship between two indexes of heart rate (HR). Seventy-eight undergraduate students, with a mean age of 21 years old, participated in this experiment. All subjects were given 32 standard stimuli (SS) and 4 interpolated test stimuli (TS). The SS for all subjects were a meaningless oral word (verbal stimulus, VS) and a circle (figure stimulus, FS). The TS for Group One, the control group, was the same as the SS. The TS for Group Two was the title of the subject´s department (VS) and an ellipse (FS). For Group Three, the TS was the subject´s name (VS) and a tringle (FS). The results of the study were as follows: (1) There was no group difference in the magnitude of OR to the changes of verbal and figure stimulus. (2) As a rule, the magnitude of OR evoked by verbal stimulus was greater than by figure stimulus. (3) There was no significant relationship between two indexes of HR.