The purpose of the study was to evaluate the effectiveness of the Health Counseling Skill Training Program ( HCSTP) for nursing students in college. Three groups were formed in the research. In the experimental group, HCSTP was implemented in a Counseling Theories and Skill Course. In the second comparison group, the Interpersonal Relationship Training Program (IRRP) was implemented in an Interpersonal Relationship course. In the control group, students received no training programs as the first two groups. Two instruments were used to assess the effects of HCSTP and IRTP on students’ health counseling skills: (1) Nurse-Patient Interaction Scale, and (2) Health Counseling Skill Practice Scale. Both instruments were administered one week before and after the course. Health counseling skills were evaluated by nursing students, mock patients, and professional counselors. A one-way analysis of covariance was conducted. Results found that: (1) HCSTP was significantly effective than IRTP on improvement of self-efficacy in nurse-patient interactions. (2) By assessing students, mock patients, and counselors’ evaluation, HCSTP-trained students got higher ratings on health counseling skills than IRTP-trained and non-trained students.