research on regret mostly discussed the effects of various types of regretted events or investigated individual differences on some cognitive characteristics to explain why regret leads to psychological well-being or illness. The authors argued that the literature on regret ignored the emotional processes in which individuals often undergo a back-and-forth self-talk. An individual examines one’s own behaviors and the consequences of one’s own doings in the forms of reflection, rumination, encouragement, or blame. In such a dialogue, an individual establishes different types of relationship with oneself, which might be a very important key to understand the way in which regret impacts psychological adjustment. In this study, we used two factors of self-compassion to index the processes of self-talk, and hypothesized that different self-compassion factors mediated the relationships between regret and psychological adjustment. The results showed that when facing regret, decent reflections increased self-compassion, which in turn increased well-being; on the other hand, it is through self-judgment which made ruminating individuals trapped in regretful mood and in turn negatively impacted well-being. The authors also discussed the role self-compassion could play when facing negative events and how self-integration is possible.