The present study attempted to compare the reactions of infants with high- and low-avoidance tendency in induced-frustration conditions.  Fifty-eight six- to twelve-months-old infants and their mothers participated.  In the experimental procedure, half of the infants were assigned to a session where they experienced his/her mother first followed by a stranger, and the other half in a session with reverse encounter order.  In each session, infants’ heart rates and crying behaviors were recorded in the baseline, cookie-offering, frustration induction, and recovery phases.  Results found that infants cried more during frustration phase than cookie-offering phase.  For the heart rates, a significant interaction was found between the avoidance and person who induced the frustration.  Compared to infants with low-avoidance, infants with high avoidance tendency had more changes changed heart rates when facing strangers.  A significant interaction between the avoidance and experimental phases was found.  Follow-up analysis found that infants with high avoidance tendency had greater changes in their heart rates during frustration than infants with low avoidance.  These findings suggested that in a mild frustration induction procedure, infants with high avoidance tendency exhibited greater changes in heart rates than those with low-avoidance in frustration, particularly in the stranger induced frustration. Understanding the reactions of infants with high avoidance tendency in frustration situation may have important implications for parenting.