The study examined the effects of a seven-year project, in which assistive technology (AT) developed by an interdisciplinary assistive technology team was used to assist individuals with severe and profound physical disabilities, on the life and development of the individuals. Four cases, including two persons with cervical spinal injuries and two persons with cerebral palsy were participants of the study. Customized high-tech devices, AT devices and services (ATDS), and AT extended services (ATES) designed for career development/transition services, vocational rehabilitation, or psychological rehabilitation were used as AT intervention to improve the individuals’abilities to actively participate in life events and their quality of life. The results indicated that positive shorter-term outcomes resulted from the AT interventions for the four cases, including ATD possessing features to meet users’needs, the completion of training goals ATD was designed to provide, and the persistence and frequency of usage of ATD by participants. . The study also showed positive long-term outcomes of the AT intervention, including extension of using ATD improved mobility and activity, increased participation performance, enhanced self-perception and satisfaction experienced by participants, and improved quality of life. Some psychosocial and social factors, such as family’s attitude and support, personal characteristics, motivation, time of onset, acceptance of impairment, and mechanisms of self-protection, could confound with the influence the AT intervention.