The purpose of this study was to combine both psychometric meta-analysis and structural equation modeling to inspect the fitness of “Personality-Stress Mode.” There were two stages in this research. In the first stage, the relationships among all of the observed variables were searched through 116 reports and 429 comparisons from the reports. Consequently, the designed coefficients among 13 observed variables all reached the significant level of .05, and therefore produced a 13x13 correlation matrix. In the second stage, an analysis was made for the fitness between “Personality-Stress Mode” and all observed data. Five aspects were discussed in this research regarding the “Personality-Stress Mode”: personality, work stress, life stress, social support, and physical and mental health. Also, all observed data were meta-analyzed. As a result, the fitness between the “Personality-Stress Mode” and all observed data was satisfactory. Before this research was done, personality was considered to be much related to work stress, life stress, social support, and physical and mental health. Social support was believed to ease off the stress. The results above supported the hypothesis of this research.