This study investigates the mechanisms of how hostility toward women affects rape. It was hypothesized that the rape myth mediates the association between hostility toward women and rape. We used an anonymous self-reporting questionnaire to conduct a survey and collect data. A representative national sample of college students was selected through a random sampling procedure, and had a valid sample of 732 male college students. The results showed that hostility toward women affected rape through rape myth; in addition, rape myth fully mediated the association between hostility toward women and rape, which supported the hypothesis of this study. Finally, the research samples and measurements, formation of hostility toward women, implications of the findings, and future research directions were addressed.