This study used qualitative and quantitative methods to examine adjustment of youths and the families as they confront challenges from societal change. Research sample focused on late-adolescent families. Data were collected in three phases: College students completed surveys in the first phase; data from past focus group interviews were used in the second phase; and data from volunteers recruited for family interview in focus groups were used in the third phase. The following results were reported: 1. Consensus and discrepancies of family system perceptions among family members. 2. Continuity and changes of family system perceptions. 3. Changes of family dynamics using Q-factor analysis. 4. Qualitative descriptions of the content, understanding, and intent of the behavioral adjustment among family members. Results indicated that college students’ perceptions of their family systems were highly correlated with mothers’ and siblings’ perceptions but not corelated with fathers’ perceptions. Qualitative data from three families were used to illustrate how the family system adjusted and adapted to societal changes. Finally, different approaches to investigate the multi-systems and dynamic family processes were also discussed.