This study examined(a) gender differences in time spent on Internet, using internet for social support, coping, loneliness, and problematic Internet use;(b) variables that could effectively predict problematic Internet use for both genders; and(c) gender difference in the mediating effects of problematic Internet use. Participants were 752 undergraduate students (393 males and 359 females) who have used the Internet. Result:(a) Males yielded higher scores than females on total number of hours spent on the Internet per week, amount of time playing games online, problematic Internet use, loneliness, and problem-focused coping. In contrast, females produced higher scores on avoidance coping, seeking social support and online social-support. (b) Loneliness, time spent on playing video games, number of hours in interpersonal interact, emotion-focused coping and avoidance coping all effectively predicted problematic Internet use for both male and female students. (c)For both male and female students, results of the SEM analysis indicated that loneliness mediated the relationship between (both emotion-focused and avoidance) coping and problematic Internet use. For female students, there is a direct effect of(both emotion-focused and avoidance) coping on problematic Internet use.